血清维生素D水平与肥胖及代谢异常关系的研究

Relationship of serum vitamin D levels with obesity and metabolic abnormalities

目的探讨血清VitD水平与肥胖及代谢异常的关系。方法 300例受试者均为2009年1～12月于我院进行健康体检的非体力劳动者。根据血清25-(OH)D水平将受试者分为VitD下降(HD)组和对照(NC)组,对两组患者BMI、血压、血脂、血糖水平及相关代谢疾病的患病情况进行比较。血清25-(OH)D水平采用ELISA检测。结果 HD组BMI、TG、LDL-C均高于NC组(P均<0.05),两组WC、SBP、DBP、FPG、TC、HDL-C差异无统计学意义。与NC组相比,HD组肥胖、腹型肥胖及高血压患病率也显著增高(P值分别为0.015、0.004、0.002)。结论血清VitD水平下降与肥胖及其代谢异常密切相关,血LDL-C是血VitD下降的独立危险因素。

Objective To investigate the relationship of serum vitamin D with obesity and metabolic abnormalities. Methods A total of 300 adults who visited Wuhan Union Hospital for a general health checkup from January to December 2009 participated in the study. They were divided into hypovitaminosis D group and control group, 150 in each, according to their serum 25-（OH） D levels. The comparisons of somatometric index, blood pressure, plasma glucose, blood lipid, and the related metabolic diseases of the two groups were carried out. The serum 25-（OH）D concentration was detected with Enzyme-linked immunosorbent assay. Result In the hypovitaminosis D group, the levels of BMI, TG, and LDL were all higher than those in the control group （all P〈0. 05）. There was no significant difference in WC, SBP, DBP, FBC-, TC, and HDL between the two groups. Compared with the control group, the prevalence of obesity （P= 0. 015）, central obesity （P = 0. 004） and hypertension （P = 0. 002） were higher in the hypovitaminosis D group. Conclusion Hypovitaminosis D is associated with obesity and metabolic abnormalities, and LDL-C is its independent risk factor.