Pim-1、RON在贲门癌中的表达及临床意义

Expressions of Pim-1 and RON proteins in the gastric cardia cancer and their clinical significances

目的:探讨Pim-1、RON在贲门癌组织中的表达及临床意义。方法:采用免疫组化方法分别检测18例贲门正常组织、21例贲门肠上皮化生组织、56例贲门癌组织中Pim-1及RON两种蛋白的表达情况,并分析二者与贲门癌临床病理学特征的关系。结果:Pim-1、RON在贲门正常组织、贲门肠上皮化生组织及贲门癌组织中的阳性表达率分别为5.6%、38.1%、78.6%和11.1%、33.3%、66.1%,各组间差异有统计学意义(P<0.05)。Pim-1的表达与浸润深度、淋巴结转移相关(P<0.05),而与性别、年龄、肿瘤分化程度、TNM分期无关(P>0.05),RON的表达与浸润深度、淋巴结转移、TNM分期相关(P<0.05),而与性别、年龄、肿瘤分化程度无关(P>0.05)。二者在贲门癌中的表达无相关性(r=0.085,P>0.05)。结论:Pim-1及RON可能参与贲门癌的发生发展,对贲门癌的诊疗及预后判断具有一定的临床价值。

Objective To investigate the expressions of Pim-1 and RON proteins in the gastric cardia cancer and their clinical significances. Methods Expression levels of Pim-1 and RON proteins in 56 cases of gastric cardia cancer tissues, 21 cases of cardia intestinal metaplasia tissues and 18 cases of normal cardiac tissues were detected using immunohistochemistry. The relationships between the expressions of Pim-1 and RON and clinical pathological characteristic were analyzed. Results The positive expression rates of Pim-1 and RON proteins in normal cardiac tissues, cardia intestinal metaplasia tissues and gastric cardia cancer tissues were 5.6%, 38.1% ,78.6% and 11.1% ,33.3% ,66.1% , respectively. There was a significant difference in the positive expression rates of Pim-1 and RON among different gastric cardia tissues （P 〈 0.05 ）. The expression of Pim-1 was related to tumor invasion depth and lymph node metastasis（P 〈 0.05）, but not to gender, age, tumor differentiation and TNM stage（P 〉 0.05）. The expression of RON was related to tumor invasion depth, lymph node metastasis and TNM stage （P 〈 0.05）, but not to gender, age, and tumor differentiation （P 〉 0.05）. There was no correlation between the expression of Pim-1 and RON in gastric cardia cancer （r = 0.085, P 〉 0.05）. Conclusion Pim-1 and RON proteins may be involved in the occurrence and development of gastric cardia cancer, which have clinical value to the diagnosis, treatment and prognosis of gastric cardia cancer.