联合检测血清SCCA、CA19-9及CA125对宫颈癌诊断及预后判断的临床意义

Clinical significance of joint detection of serum SCCA,CA_(199),and CA_(125) for diagnosis and prognostic evaluation of cervical cancer

目的:观察联合检测血清SCCA、CA19-9和CA125水平在宫颈癌诊断及预后判断中的临床意义。方法:收集2007年1月～2011年12月收治的105例宫颈癌患者(宫颈癌组)及同期健康体检的40例妇女(对照组),分别检测血清肿瘤标志物SCCA、CA19-9和CA125水平,分析其与宫颈癌及临床分期、病理类型的关系,并观察其在初诊和复发病例中的含量差异。结果:与对照组比较,宫颈癌组血清SCCA、CA19-9和CA125含量和阳性率均显著增高,且其含量的高低与宫颈癌的临床分期密切相关;同时复发病例上述指标水平均显著高于初诊病例;SCCA在宫颈鳞癌中的水平和阳性率均显著高于宫颈腺癌,而CA19-9和CA125在宫颈鳞癌中的水平和阳性率均显著低于宫颈腺癌。结论:联合检测血清肿瘤标志物SCCA、CA19-9和CA125水平有助于宫颈癌的诊断和对其预后与病理类型的判断。

Objective： To observe the clinical significance of joint detection of serum squamous cell carcinoma antigen （SCCA） , CAI99, and CA125 for diagnosis and prognostie evaluation of cervical cancer. Methods： One hundred and five patients with cervical cancer （cervical cancer group） who were treated in the hospital from January, 2007 to December 2011 and forty women who received physical exami- nation during the same period （control group） were collected, the serum levels of SCCA, CA199 , and CA125 in the two groups were detected respectively; their relationships with cervical eancer, clinical stages, and pathological types were analyzed; the differences of the levels between patients of preliminary diagnosis and recurrent patients were observed. Results： Compared with control group, the serum contents and positive rates of SCCA, CA199, and CA12s in cervical cancer group increased significantly, and the contents were correlated with clinical sta- ges of cervical cancer; the serum contents and positive rates of SCCA, CA199, and CA125 in recurrent patients were significantly higher than those in patients of preliminary diagnosis; the serum level and positive rate of SCCA in cervical squamous cell careinoma were significantly higher than those in cervical adenocarcinoma; but tile serum levels of CA199 and CA125 in cervical squamous cell carcinoma were significantly lower than those in cervical adenocareinoma. Conclusion： Joint detection of serum SCCA, CA199 , and CA125 is conducive to diagnosis of cervical cancer and prediction of prognosis and pathological types.