血清抑制素B早期预测卵巢储备功能下降及干预治疗的临床价值

Clinical values of serum inhibin B and interventional therapy for early predicting decline of ovarian reserve function

目的:探讨血清抑制素B(INHB)早期预测卵巢储备功能的临床价值及干预治疗后对其妊娠率的影响。方法:通过检测血清抑制素B水平筛查出202例卵巢储备功能下降导致不孕的患者,随机分为A、B两组各101例。A组未经治疗直接促排卵,B组经人工周期治疗后促排卵,观察两组的周期妊娠率、临床妊娠率及B组治疗前后激素水平的变化。结果:A组周期妊娠率、临床妊娠率均低于B组,差异均有统计学意义(P<0.05);B组INHB水平治疗后较治疗前升高,差异有统计学意义(P<0.05)。结论:血清INHB水平可作为临床早期预测卵巢储备功能下降的指标之一。尽早给予合理的性激素治疗可使卵巢功能得到改善,提高妊娠率。

Objective： To explore the clinical value of serum inhibin B for early predicting decline of ovarian reserve function and the effect of interventional therapy on pregnancy rate. Methods： Two hundred and two patients with decline of ovarian reserve function - in- duced infertility who were screened out by detecting inhibin B level were randomly divided into group A and group B, 101 patients in each group. The patients in group A received direct ovulation induction without treatment, while the patients in group B received ovulation induc- tion after artificial menstrual cycle. The cycle pregnancy rates and clinical pregnancy rates in the two groups and changes of hormones levels before and after treatment in group B were observed. Results： The cycle pregnancy rate and clinical pregnancy rate in group A were statisti- cally significantly lower than those in group B （ P 〈 0. 05 ） ; inbibin level after treatment was statistically significantly higher than that before treatment in group B （P 〈 0. 05 ） . Conclusion ： Serum inhibin B level can be used as one index to early predict decline of ovarian reserve function, early and reasonable sex hormone therapy can improve ovarian function and raise pregnancy rate.