MTA1在子宫内膜异位症中的表达及意义

Expression and significance of MTA1 in endometriosis

目的:研究MTA1在子宫内膜异位症中的表达及意义。方法:应用免疫组化方法对30例子宫内膜异位症在位内膜,异位内膜及20例正常内膜组织进行MTA1的表达检测。结果:正常内膜MTA1阳性率为30.0%(6/20),异位内膜阳性表达率53.3%(16/30),在位内膜阳性表达率73.3%(22/30),在位内膜与正常内膜MTA1表达阳性率比较有统计学差异(P=0.002),正常内膜与异位内膜MTA1表达阳性率比较无统计学差异(P=0.103),在位内膜与异位内膜MTA1表达阳性率比较无统计学差异(P=0.108),MTA1在各组间增生期及分泌期表达阳性率比较,无统计学差异(P>0.05)。结论:MTA1在在位内膜中的过度表达在子宫内膜异位症发生、复发过程中可能起一定的作用,这将为子宫内膜异位症的治疗和预后判断提供新的线索。

Objective： To research the expression and significance of MTA 1 in endometriosis. Methods： The expression levels of MAT1 in eutopie endometrium and ectopic endometrium of 30 cases with endometriosis and normal endometrium of 20 cases without endome- triosis were detected by immunohistochemical method. Results： The positive rates of MTA1 in normal endometrium, ectopic endometrium, and eutopic endometrium were 30.0% （6/20）, 53.3% （ 16/30）, and 73.3% （22/30）, respectively, there was statistically significant difference in positive expression rate of MTA1 between eutopic endometrium and normal endometrium （ P = 0. 002 ） , there was no statistically significant difference in positive expression rate of MTA1 between normal endometfium and ectopic endometrium （ P = 0. 103 ） , there was no statistically significant difference in positive expression rate of MTA1 between eutopic endometrium and ectopic endometrium （ P = 0. 108 ） , there was no statistically significant difference in positive expression rates of MTA1 at proliferative phase and secretory phase among normal endometrium, ectopic endometrium, and eutopic endometrium （ P 〉 0. 05 ） . Conclusion： Over - expression of MTA1 in eutopic endometri- um may play a ceratin role in occurrence and development of endometriosis, which provides a new clue for treatment and prognostic evalua- tion of endometfiosis.