摘要
目的观察右美托咪定与咪达唑仑对腹腔镜胆囊术全麻患者气管插管拔管期心血管应激反应的影响。方法 100例合并高血压行腹腔镜胆囊切除患者随机分为两组,两组患者均采用相同全麻诱导和维持,右美托咪定组诱导前10 min内静脉泵注1μg/kg右美托咪定,咪达唑仑组同速度同容量静射0.05 mg/kg咪达唑仑。观察两组诱导前、拔管时及拔管后1、5、10 min时的SBP、DBP、HR、心率和收缩压的乘积(RPP)。结果与咪达唑仑组比较,右美托咪定组拔管时、拔管后1 min的SBP、DBP、HR、RPP降低,拔管后5 min的RPP亦降低(P均<0.05);与同组诱导前比较,咪达唑仑组拔管时、拔管后1 min的SBP、DBP、HR、RPP升高,拔管后5 min的RPP亦升高(P均<0.05)。结论相对于咪达唑仑,右美托咪定能有效减轻腹腔镜胆囊切术全麻患者气管插管拔管期心血管应激反应,增加拔管时的安全性。
Objective To investigate the effects of dexmedetomidine and midazolam on cardiovascular response of general anesthesia patients undergoing laproscopic cholecystectomy （LC） during decannulation period. Methods One hundred patients with hypertension underwent LC were randomly divided into two groups. The scheme of induction and ma- intenance of anesthesia of the two groups were identical. However, patients in dexmedetomidine group were administered with dexmedetomidine 1μg/kg over 10 mins and midazolam 0.05 mg/kg over 10 mins in midazolam group. Before induction, at the time of extubation and 1 min post extubation, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, heart rate （HR）, the recovery time, extubation time and adverse effects were recorded, RPP were also calculated. Results SBP, DBP, HR, RPP in dexmedetomidine group at the time of extubation and 1 min post extubation were significantly lower than those in midazolam group. And even 5 min post extubation, RPP value in dexmedetomidine group was still sig- nificantly lower than that in midazolam group （ all P 〈 0.05）. In addition, the above parameters were statistically elevated in midazolam group at extubation and 1 min post extubation compared to parameters before induction （ all P 〈 0.05）. Conclusions Dexmedetomidine can effectively attenuate the cardiovascular response to extubation in patients with hypertension undergoing laproscopic cholecystectomy and also can strengthen the safety degree of tracheal extubation.
出处
《山东医药》
CAS
2013年第3期50-52,共3页
Shandong Medical Journal
基金
泸州市科技计划资助项目(2012-s-37)
