胱抑素C与糖尿病肾病的相关研究进展

Research Progress of Cystatin C and Diabetic Nephropathy

糖尿病肾病是糖尿病的主要慢性并发症之一。在欧美、日本等发达国家,糖尿病是导致终末期肾衰竭的主要诱因。肾小球滤过率是反映肾功能的主要指标。近年来,国内外大量研究证明血清胱抑素C不受性别、年龄、炎症反应、肿瘤、肌肉量、饮食摄入等因素的影响,是反映肾小球滤过率理想的内源性标记物,因而可替代肌酐等指标用于糖尿病肾病的早期诊断。本文就胱抑素C与糖尿病肾病的相关研究进展做一综述。

Diabetic nephropathy is a major chronic complication of diabetes. In Europe and America, Japan and other developed countries, diabetes is the leading cause for ESRD. Glomerular filtration rate （GFR） is a key indicator for renal function. In recent years, many domestic and international studies have shown that Cystatin C could be used as an ideal endogenous marker of GFR based on the fact that, unlike creatinine, cystatin C levels are generally not influenced by extra - renal factors such as gender, age, inflarhmatory reaction, muscle mass and diet intake, so it can replace creatinine and other indicators used in the early diagnosis of diabetic nephropathy. This paper summarizes related research progress on Cystatin C and diabetic nephropathy.