失读症儿童磁共振脑成像研究——优化体素形态学分析

A Voxel-Based Morphometry Approach to the Brain Differences between Dyslexic and Normal Children-an MRI Study

使用3.0T磁共振扫描仪对15位失读症儿童和15位正常儿童进行脑部T1加权成像,在Matlab和SPM8环境下运用优化体素形态学方法对两组受试脑灰质和脑白质容量进行对比分析,结果显示:失读症儿童和正常儿童的整体脑容量没有显著性差异(灰质p=0.664,白质p=0.598,脑脊液p=0.145,脑总容量p=0.447);但与正常儿童相比,失读症儿童左脑额中回(left middle frontal gyrus)灰质和左脑颞中回(left middle temporal gyrus)白质脑容量低于正常儿童(puncorr<0.001)。研究表明,儿童失读症可能与左脑语言区灰质、白质容量降低有关。

Analyze morphometric differences between dyslexic children and normal children using 3.0 T MR machine to acquire Tl-weighted brain images of 15 dyslexic children and 15 normal children. Optimized voxel - based morphometrical analysis shows there is no significant difference between dyslexic and normal children in terms of global volume of gray matter and white matter （ GM p =0.664, WM p = 0. 598, CSF p = 0. 145, Total p = 0. 447 ）. Campared with normal children, dyslexic children have lower gray matter volume in the left middle frontal gyrus and white matter volume in the left middle temporal gyrus （ puneorr 〈 0. 001 ）. The study shows children＇s dyslexia is related to the abnormalities in gray matter and white matter in the language area of the brain.