药品不良反应信号检测中遮蔽效应的影响及消除方法

Masking Effect in the Process of Signal Detection of Adverse Drug Reaction

常规的药品不良反应信号检测方法基于不相称测定理论,在药品不良反应监测中发挥着重要的作用。然而这些方法在信号检测准确性中存在一些缺陷,无法很好地解决一些现象,如遮蔽效应等。这些现象需要基于新的策略对数据进行分析,本文介绍遮蔽效应对信号检测准确性的影响,以及如何发现和消除遮蔽效应的研究进展。

Routine adverse drug reaction signal detection methods based on disproportionality analysis are playing important role in the process of adverse drug reaction surveillance. However, these methods have their own drawbacks in the accuracy for signal detection and could not solve some problems which include masking effect. These problems should be solved through new analysis strategy. In this article, we present the impact of masking effect on the signal detection and introduce the latest research on the identification and elimination of masking effect.