长QT综合征和自主神经系统

Long QT Syndrome and Autonomic Nerve System

大量临床证据和实验结果均提示自主神经和长QT综合征(LQTS)的发病有关,该领域的研究日益受到学界的重视。近十年来,研究人员在自主神经与LQTS临床特征、发病机制以及治疗方面都有许多重要成果,如刚刚发表的证据就表明普萘洛尔缩短QT间期、治疗LQTS的效果明显优于美托洛尔,提示不同的β受体阻滞剂对LQTS疗效不同。随着对自主神经在LQTS中的发病机制的进一步深入研究,有可能找到更加有效的方法来指导LQTS的预防、诊断和治疗。

A large number of clinical data and experimental results have indicated that the autonomic nervous system has effects on the onset of arrhythmias of LQTS patients, Interests in the relationship between autonomic nervous system and LQTS is increasing. Many impor- tant results have been concluded on the clinical features, for example, propranolol is better than metoprolol in decreasing of QTc and preven- ting cardiac events for LQTS patients. These autonomic nervous system interactions provide new insights into future novel therapies to LQTS.