尼莫地平不同给药途径防治蛛网膜下腔出血脑血管痉挛效果分析

Effect analysis of Nimodipine with different administration route for cerebral angio spasm on subarachnoid hemorrhage

目的探讨尼莫地平不同给药途径防治蛛网膜下腔出血脑血管痉挛的临床效果。方法选择40例蛛网膜下腔出血患者使用尼莫地平鞘内注射,并与40例使用静脉注射的蛛网膜下腔出血患者比较,比较两组患者治疗后发生的不良反应并统计治疗的临床效果。结果鞘内组发生低血压、心率增快和头痛比率均为2.5%,静脉注射组发生低血压、心率增快和头痛比率为15.0%、17.5%和15.0%,鞘内注射组低血压、心率增快和头痛比率低于静脉注射组(P<0.05),鞘内组发生颅内血管痉挛的比率仅为2.5%,静脉组为17.5%,鞘内注射组低于静脉注射组(P<0.05)。结论鞘内注射尼莫地平能有效预防网膜下腔出血后脑血管痉挛,改善临床治疗效果。

Objective To investigate the clinical effect of Nimodipine with different administration route for cerebral angio spasm on subarachnoid hemorrhage. Methods Forty cases of patients with subarachnoid hemorrhage were select- ed and taken nimodipine intrathecal injection, and 40 cases of patients with subarachnoid hemorrhage were taken ni- modipine with intravenous injection, incidence rate of untoward reaction and clinical effect were contrasted. Results Incidence rate of hypotension, heart rate accelerating and headache was 2.5%, 2.5% and 2.5% in intrathecal injection group, and was 15.0%, 17.5% and 15.0% in intravenous injection group, incidence rate of hypotension, heart rate ac- celerating and headache was lower in intrathecal injection group than that in intravenous injection group （P 〈 0.05）. Incidence rate of cerebral angio spasm was 2.5% in intrathecal injection group, and was 17.5% in intravenous injec- tion group, incidence rate of cerebral angio spasm was lower in intrathecal injection group than that in intravenous in- jection group （P 〈 0.05）. Conclusion Nimodipinc intrathecal injection can prevent efficiently cerebral anglo spasm on subarachnoid hemorrhage, and improve clinical effect.