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DACH1在肿瘤细胞中的作用机制探讨 被引量：2

Investigation on the mechanism of DACH1 in tumour cells
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摘要 细胞命运决定因子DACH1在肿瘤细胞尤其是激素依赖性肿瘤细胞中的表达与肿瘤的发生发展关系密切,但是其确切的作用机制还没有形成统一的认识。DACH1可能主要是通过对TGF-β信号通路及细胞周期蛋白表达的影响来发挥作用,是一种潜在的抑癌基因。 Cell fate determination factor DACH1 is homologous of drosophila dac and found in mammalian. Its expression in tumour cells, especially in hormone dependence tumours plays an important role in the development of tumour. But the exact mechanism has not formed a unified understanding. DACH1 may play a role through TGF-β signaling and cell cycle protein as a potential tumor-suppressor gene.
作者 周定心 刘尚勤
机构地区 武汉大学中南医院血液科
出处 《中国当代医药》 2013年第4期26-27,共2页 China Modern Medicine
关键词 细胞命运决定因子DACH1 转化生长因子-Β 细胞周期蛋白D1 激活蛋白-1 Cell fate determination factor DACH1 Transforming growth factor-β Cyclin D1 Activator protein-1
分类号 R34 [医药卫生—基础医学]
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参考文献11

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同被引文献9

  • 1YUKIO SONODA. Surgical treatment for apparent early stage endometrial cancer[J]. Obstet Gynecol Sci, 2014, 57(1): 1-10.
  • 2VISNOVSKY J, FIOLKA R, KUDELA E, et al. Hypermethylation of selected genes in endometrial carcinogenesis[J]. Neuroendocrinology Letters, 2013, 34(7): 675-680.
  • 3YAN W, WU K, HERMAN JG, et al. Epigenetic regulation of DACH1, a novel Wnt signaling component in colorectal cancer[J]. Epigenetics, 2013, 8(12): 1373-1383.
  • 4OZTURK E, DIKENSOY E, BALAT O, et al. Association of en- dothelial nitric oxide synthase gent polymorphisms with endome- trial carcinoma: a preliminary study[J]. Journal of the Turk- ish-German Gynecological Association, 2011, 12(4): 229-233.
  • 5ZHU H, WU K, YAN W, et al. Epigenetic silencing of DACH1 induces loss of transforming growth factor-β1 antiproliferative re- sponse in human hepatocellular carcinoma[J]. Hepatology, 2013, 58(6): 2012-2022.
  • 6LEE JW, KIM HS, KIM S, et al. DACH1 regulates cell cycle progression of myeloid cells through the control of eyelin D, Cdk 4/6 and p21Cipl[J]. Biochemical and biophysical Research Com- munications, 2012, 420(1): 91-95.
  • 7GOKSEDEF B PC, AKBAYIR O, CORBACIOGLU A, et al. Comparison of preoperative endometrial biopsy grade and final pathologic diagnosis in patients with endometrioid endometrial cancer[J]. Journal of the Turkish-German Gynecological Associ- ation, 2012, 13(2): 106-110.
  • 8黄启成,陆锦标,汤春晖.子宫内膜癌中SFRP1基因启动子甲基化及其mRNA表达[J].第二军医大学学报,2010,31(4):450-452. 被引量：1
  • 9符策岗,汪磊,宋银宏.抑癌基因甲基化与宫颈癌的关系[J].生命科学,2013,25(1):63-67. 被引量：8

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中国当代医药
2013年 第4期

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