83例药源性死亡病例回顾及分析

Review and analysis of 83 cases of Drug-induced deaths

目的了解药源性死亡病例的情况。方法检索2000～2012年《中国期刊全文数据库》中收录的药源性死亡病例,按性别、年龄、给药途径、药品品种、致死药品品种分布、器官系统损害进行分类统计和分析。结果按给药方式:静脉注射和口服给药致死率分别为49.40%和21.69%;按致死药品品种:抗感染药物和中药制剂分别占致死频次的41.75%和18.45%;按受累系统:全身性反应、消化系统、呼吸系统居前3位。结论应加强临床合理用药,确保临床用药安全,减少药害事件的发生。

Objective To investigate the cases of drug-induced deaths. Methods The drug-induced death cases re ported on China Journal Full-text database from 2008 to 2012 were r^trieved, and they were given classified statistics and analysis according to gender, sex, route of administration, drug varieties, lethal drugs variety distribution and organ system damage classification. Results According to the administrative way： intravenous and oral dosing to death rates were 49.40% and 21.69% respectively; according to the lethal drugs： anti-infective drugs and traditional Chinese medicine preparation were lethal at frequencies of 41.75% and 18.45% respectively; according to the affected system： involvement of systemic reactions, digestive system, respiratory system were ranked in the top 3. Conclusion We should strengthen the rational clinical drug use, ensure the clinical medication safety, reduce the occurrence of hazard events by drugs.