聚氨基酸胶束在肿瘤治疗中的研究进展

Progress in research of poly amino acid micelles in cancer therapy

聚氨基酸胶束是一类新型的聚合物胶束,具有高效、长效及药量高载等特点。抗肿瘤药物通过化学结合或物理包裹的方式进入胶束内部,具有较高的稳定性。同时,在EPR(Enhanced Permeability and Retention,EPR)效应作用下,聚氨基酸胶束纳米粒可以有效地蓄积于肿瘤组织中达到很好的抗肿瘤效果,并减少药物在其他正常组织中的分布而降低毒副作用。本文综述了聚天冬氨酸、聚谷氨酸和聚赖氨酸三类聚氨基酸胶束作为抗肿瘤药物载体的理化性质、特点及其相关临床研究进展,对各个研究实例进行简要介绍。

Poly amino acid micelle is one of the new polymeric micelles, with considerable advantages of high efficiency, long-acting and high drug-loading in cancer therapy. Polymeric micelles are expected to incorporate the antitumor drugs into the inner core by chemical conjugation or physical entrapment and to increase the accumu- lation of drugs in tumor tissues utilizing the EPR effect. Thus they can achieve a good antitumor effect, decrease the distribution of drugs in the normal tissue and reduce the incidence of side effects. In this paper, we summarized the characteristics and the preparation of the polyaspartie acid, polyglutamic acid, and polylysine micelles for antican- eer drugs, and the progress of the related clinical research; and briefly introduced each research case.