非小细胞肺癌介入治疗前后HIF-1α和VEGF水平的动态变化及相关性研究

Study on dynamic changes and correlation of serum HIF-1α and VEGF Levels before and after interventional treatment on non-small cell lung cancer

目的探讨非小细胞肺癌介入治疗前后缺氧诱导因子-1α(HIF-1α)和血管内皮生长因子(VEGF)水平的动态变化及相关性。方法选择2010年2月～2012年2月于我院接受诊断和治疗的非小细胞肺癌患者96例,随机分为观察组与对照组,每组48例。观察比较两组患者介入治疗前后HIF-1α和VEGF水平的动态变化及相关性。结果观察组与对照组的血清HIF-1α和VEGF含量差异有统计学意义(P<0.05),不同时间点间的血清HIF-1α和VEGF含量差异有统计学意义(P<0.05);组间与不同时点的交互作用有统计学意义(P<0.05)。患者血清HIF-1α和VEGF含量呈正相关性(r=0.485,P<0.05)。结论非小细胞肺癌介入治疗后HIF-1α和VEGF水平明显升高且呈正相关性,但其升高程度明显小于接受常规治疗的患者。

Objective To discuss the dynamic changes and correlation of serum HIF-1α and VEGF levels before and after interventional treatment on non-small cell lung cancer.Methods 96 patients with NSCLC in our hospital from February 2010 to February 2012 were selected and randomly divided into the observation group and the control group with 48 cases in each group.The dynamic changes and correlation of serum HIF-1α and VEGF levels before and after interventional treatment on NSCLC were observed and compared.Results The differences of serum HIF-1α and VEGF levels between the observation group and the control group were statistical significance（P 0.05）.The differences of serum HIF-1α and VEGF levels at different time points were statistical significance（P 0.05）.The differences of interactions between the two groups and different time points were statistical significance（P 0.05）.The positive correlation of serum HIF-1α and VEGF levels before and after interventional treatment was found.Conclusion The serum HIF-1α and VEGF levels have an obvious increase after interventional treatment of non-small cell lung cancer patients and have a positive correlation.