血糖波动及降钙素基因相关肽对糖尿病微血管病变影响的研究进展

Blood glucose fluctuation,Calcitonin gene-related peptide and diabetic microangiopathy

随着动态血糖监测系统(CGMS)的广泛使用,使人们注意到波动性高血糖比持续性高血糖更易促进糖尿病微血管病变的发生和发展。降钙素基因相关肽是目前知道的舒血管活性最强的多肽,在糖尿病微血管病变中起着重要的作用。相信对血糖波动危害的正确认识及降钙素基因相关肽对糖尿病微血管病变影响机制的深入研究,能够为糖尿病(DM)的诊治提供依据和手段,改善患者的预后。

With the widespread use of continuous glucose monitoring system （CGMS）, it was noticed that blood glucose fluctuation is easier to induce the occurrence and progression of diabetic microangiopathy than persistent hyperglycemia. Calcitonin gene-related peptide（CGRP）is presently known as the most powerful vasodilator peptide in the body which plays an important role in diabetic microangiopathy. It was believable that proper consciousness of the glucose fluctuation and deeper study of the CGRP may provide a new method of diagnosis and treatment for diabetes mellitus （DM）, which will lead to prognosis improvement.