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西黄解毒胶囊控制大肠癌术后复发转移临床研究 被引量:13

Clinical Research of Xihuang Jiedu Capsule in Reducing Post-operational Relapse and Metastasis of Colorectal Cancer
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摘要 目的:观察西黄解毒胶囊对Ⅲ期大肠癌术后患者复发转移的影响。方法:将52例大肠癌术后患者为随机分为对照组与治疗组,每组26例,两组均应用规范的术后辅助放化疗,治疗组同时联合西黄解毒胶囊,观察两组中位复发转移时间、1~3年复发转移率及患者生活质量影响。结果:大肠癌患者术后1年、2年、3年复发转移率对照组分别为41.66%,79.16%和91.66%;治疗组分别为15.38%,50.00%和57.69%,治疗组与对照组比较,术后第2、3年有统计学差异(P<0.05及P<0.01),大肠癌患者术后中位复发转移时间对照组为14个月,治疗组为21个月,两组有统计学差异(P<0.05)。治疗组治疗前后KPS评分分别为73.35±6.21和81±5.47,统计学有明显差异(P<0.05)。结论:大肠癌患者应用西黄解毒胶囊可以降低术后复发转移,改善生活质量。 Objective:To observe the relapse and metastasis of Xihuang Jiedu Capsule in reducing post-operational patients with colorectal cancer of stageⅢ.Methods:Adopting prospective randomized controlled method,a total of 52 post-operational patients with colorectal cancer of stageⅢwas assigned to a treatment group and a control group,26 cases in each.Both groups were received standard radiotherapy and chemotherapy.Additionally,the treatment group was administered Xihuang Jiedu Capsule.The median time of relapse-metastasis,relapse-metastasis rate of 1~3 years and quality of life of both groups were observed.Results:The 1year,2year and 3year relapse and metastasis rate in the control group was 41.66%,79.16%and 91.66%;and in the treatment group that was 5.38%,50.00%and 57.69%Respectively, 2 year and 3 year relapse and metastasis rate showing significant difference between the two groups(P0.05 and P0.01).Difference in median time of relapse and metastasis between the two groups(14 months vs 21 months) also showed statistical significance(P0.05).The KPS in the treatment group was 73.35±6.21 before treatment and 81±5.47 after treatment,respectively,showing significant improvement(P0.05).Conclusion:Xihuang Jiedu Capsule can reduce post-operational prelapse and metastasis in patients with colorectal carcinoma.While Xihuang Jiedu Capsule shows favorable effect on improving quality of life of colorectal carcinoma patients.
出处 《中华中医药学刊》 CAS 2013年第1期72-73,共2页 Chinese Archives of Traditional Chinese Medicine
基金 北京市自然科学基金资助项目(7122151) 第四批首都名老中医药专家学术经验传承项目(京中医科字[2011]47号
关键词 大肠癌 复发转移 西黄解毒胶囊 colorectal cancer relapse and metastasis Xihuang Jiedu Capsule
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