摘要
目的:研究五加菌丝体胶囊对小鼠免疫功能的影响,为评估其保健药用价值提供参考。方法:检测高中低剂量组1.00、0.67、0.33 g·kg^(-1)·d^(-1)给小鼠服药后ConA诱导的脾淋巴细胞转化率,二硝基氟苯(DNFB)诱导迟发型变态反应,抗体生成细胞数及血清溶血素的生成等4项免疫学指标。结果:各剂量组对小鼠迟发型变态反应,血清溶血素的生成均有明显增强效应,高剂量组对脾淋巴细胞转化率,抗体生成细胞有提高效应。结论:提示该胶囊具有一定的免疫增强功能,是其对肿瘤康复治疗有效的机理之一。
Objective:To study the immunity enhancement activity of Wujiajunsiti Capsule.Method:The level of ConA-induced spleen cell transformation was tested and compared between the groups of mice,which were fed with the high, medium and low dose groups of drug(1.00、0.67、0.33 g·kg^(-1)·d^(-1)),and those which were not(control group).The level of dinitrofluorobenzene(DNFB)-induced delayed type hypersensitivity,the number of antibody-producing cells and serum hemolysin fonnation were also tested and compared.Result:Tests showed that the high,medium and low dose groups of drug can enhance the level of DNFB-induced delayed type hypersensitivity and serum hemolysin formation. And only the high dose group can enhance the level of ConA-induced spleen cell transformation and the number of antibody-producing cell.Conclusion:Results show that the capsule has a strong immune enhancement activity,so it could be used in recovery therapy against tumor.
出处
《中华中医药学刊》
CAS
2013年第1期111-112,共2页
Chinese Archives of Traditional Chinese Medicine
基金
上海市教委重点学科中西医结合基础资助项目(J50301)
海门市科委科研项目[海科发2007-9(12)]
关键词
五加菌丝体胶囊
免疫效应
肿瘤康复调理
Wujiayunsiti Capsule
immunity enhancement
recovery therapy against tumor