特异性免疫治疗过敏性哮喘患儿50例疗效观察

Observation on the curative effect of specific immunotherapy in the treatment of 50 children patients with allergic asthma

目的:探讨特异性免疫治疗过敏性哮喘患儿的疗效及对肺功能的影响。方法:选择96例对螨变应原测试阳性的过敏性哮喘患儿作为观察对象,随机分为特异性免疫治疗组50例和对照组46例,两组均采用GENA方案吸入糖皮质激素治疗,药物为丙酸氟替卡松(辅舒酮)气雾剂和沙美特罗替卡松粉吸入剂(舒利迭),特异性免疫治疗组实施特异性免疫疗法。分别于3个月、6个月、1年、2年进行疗效判定、简易肺功能检测。结果:特异性免疫治疗可明显改善过敏性哮喘患儿症状,患儿哮喘发作次数减少,肺功能改善优于对照组,差异有统计学意义(P<0.05)。结论:特异性免疫治疗过敏性哮喘疗效显著,且疗程与疗效成正相关。

Objective ：To explore the curative effect of specific immunotherapy in the treatment of children patients with allergic asthma and its influence on the pulmonary function. Methods .96 children patients with allergic asthma （mite allergen was positive） were taken as the objects of observation and they were randomly divided into the specific immunotherapy group （ n = 50 ） and the control group （ n = 46 ）. The patients in the two groups were treated with glncocorticoid inhalation therapy by following GENA scheme （flixotide aerosol and Seretide Evohaler） and the specific immunotherapy was extra used in the specific immunotherapy group. The evaluation of the curative effect and simple test of pulmonary function were carried out respectively in 3 months,6 months, one year and 2 years. Results：The specific immunotherapy can markedly improve the symptoms of children patients with allergic asthma and reduce frequency of attacks, the improve- ment of lung function of the patients was better in the specific immunotherapy group than the control group and the difference between the two groups was statistically significant（P 〈 0.05 ）. Conclusions ： The curative effect of the specific immunotherapy is significant in the treatment of children patients with allergic asthma.