妊娠高血压综合征患者血浆D-D与FDP检测的临床意义

Clinical significance of D-D and FDP in pregnancy induced hypertension

目的探讨妊娠高血压综合征患者体内D-二聚体(D-D)、纤维蛋白(原)降解产物(FDP)水平及其临床意义。方法选取孕25～30周妊娠妇女150例,其中妊娠合并高血压患者73例,正常妊娠妇女77例,选择健康人群75例作为对照组。入院或体检时即采集静脉血,进行血浆D-D、FDP检测。结果妊娠合并高血压患者血浆D-D、FDP水平与正常妊娠妇女及健康体检人群比较,差异具有统计学意义(P<0.05);正常妊娠妇女血浆D-D、FDP水平与健康体检人群相比较,差异无统计学意义(P>0.05)。结论血浆D-D、FDP水平与妊娠合并高血压密切相关,监测D-D、FDP水平有助于提示妊娠合并高血压的可能,对于妊娠合并高血压的及时发现、治疗和预防有重要的临床意义。

Objective To explore the levels of D-D and FDP in pregnancy induced hypertension and their clinical implications.Methods 150 women with 25-30 weeks pregnant were divided into two groups,one group included 73 pregnancy induced hypertension,another included 77 normal pregnancy,75 healthy people were enrolled as control group.Venous blood samples were collected from all groups and D-D,FDP were determined.Results The levels of D-D,FDP in pregnancy induced hypertension were higher than normal pregnancy and healthy people（P0.05）.There were no significant difference between normal pregnancy and healthy people in levels of D-D and FDP（P0.05）.Conclusion The levels of D-D,FDP are close related with pregnancy induced hypertension.So it is important to monitor them for discovery,treatment and prevention of pregnancy induced hypertension.