70例老年戊型病毒性肝炎的临床分析

Clinical analysis of 70 elderly patients with viral hepatitis E

目的探讨老年戊型病毒性肝炎的临床特点。方法观察60岁以上的戊型肝炎患者的临床表现、并发症、治疗及转归。结果老年戊型病毒性肝炎发病率有逐渐上升的趋势,重症肝炎多,病死率高;均有黄疸(100.0%),重度黄疸比例高(60.0%)。老年戊型病毒性肝炎患者多有基础慢性疾病,并发症多,病程长。结论随着人口老龄化,老年戊型病毒性肝炎发病率增高。因老年人肝脏结构和功能改变、免疫力低下、多种慢性病并存、免疫力下降,易延误戊型病毒性肝炎的早期诊断及治疗,导致病情重、病程长,影响预后。

Objective To investigate the clinical features of viral hepatitis E in elderly patients. Methods The clinical manifestations, complications, treatment and outcome of patients with hepatitis E over the age of 60 were observed. Results The incidence rate of hepatitis E in elderly patients was gradually rising, with more patients with severe hepatitis and high mortality. All the patients had jaundice （100.0%）, with high proportion of severe jaundice （60.0%）. Most of the patients had underlying chronic diseases, many complications and long disease course. Conclusion With the aging of population, the incidence of hepatitis E in elderly patients increases. Due to the changes of liver structure and function, low immunity, coexistence of several chronic diseases and decline of response, early diagnosis and treatment of viral hepatitis E may be delayed, leading to severe conditions, long disease course and poor prognosis.