老年脓血症患者检测血浆NAP和hs-CRP的临床价值

Clinical value of plasma NAP and hs-CRP for elderly patients with sepsis

目的探究分析老年严重脓血症患者血浆超敏C反应蛋白(hs-CRP)和中性粒细胞碱性磷酸酶(NAP)水平的改变并讨论其临床意义。方法选取本院收治的老年严重脓血症患者65例,作为A组实验组。选取同期入院治疗的非脓血症老年患者65例,作为B组对照组。在患者入院后的第1天测量并记录两组患者的血浆hs-CRP和NAP水平,比较两组患者血浆hs-CRP和NAP水平的变化情况。结果 A组患者NAP和hs-CRP水平明显高于B组,差异有高度统计学意义(P<0.01)。实验组20例患者死亡,死亡患者NAP和hs-CRP水平明显高于生存组患者,差异均有统计学意义(P<0.05)。结论 NAP和hs-CRP是反映老年脓毒血症患者危重程度和预后的重要和准确的指标。

Objective To explore clinical value of altered levels of high sensitivity C-reactive protein （hs-CRP） and neutrophil alkaline phosphatase （NAP） for elderly patients with sepsis. Methods Sixty five cases of elderly patients with severe sepsis in our hospital were selected to Group A as the experimental group. 65 cases of non-sepsis elderly patients the same period in hospitalization were selected to Group B as the control group. The hs-CRP and NAP level of two groups with plasma were recorded in the first day after admission. The changes of plasma hs-CRP and NAP level of two groups were compared. Results NAP and hs-CRP levels of group A were significantly higher than that of group B, the differences were statistically significant （P 0.01）. There were 20 patients died in group A. The NAP and hs-CRP levels in death patients were significantly higher than that of survival patients, the differences were statistically significant （P 0.05）. Conclusion NAP and hs-CRP are important and accurate indicators to reflect the critical extent and prognosis of elderly patients with sepsis.