急性冠状动脉综合征患者血清超敏C-反应蛋白及尿酸的改变及其与动脉狭窄程度的关系

The relationship of change of hypersensitive C-reactive protein,uric acid and coronary artery stenosis degree in the patients with acute coronary syndrome

目的探讨急性冠状动脉综合征患者血清超敏C反应蛋白(hs-CRP)、尿酸的改变及二者与冠状动脉狭窄的关系。方法选择经冠状动脉造影证实为急性冠状动脉综合征的80例患者为研究对象,其中不稳定型心绞痛患者45例,急性心肌梗死患者35例。选择同期体检的30例健康者为对照组,比较三组血清hs-CRP及尿酸水平并探讨二者与急性冠状动脉综合征患者动脉狭窄的关系。结果不稳定型心绞痛及急性心肌梗死患者血清hs-CRP、尿酸水平显著高于对照组(P<0.05),但二者之间差异无统计学意义(P>0.05);随着急性冠状动脉综合征患者冠状动脉病变支数的增加,患者血清hs-CRP及尿酸水平显著增高(P<0.05);Pearson相关分析结果显示:血清hs-CRP及尿酸水平显著相关(r=0.387,P<0.05)。结论 hs-CRP及尿酸可能通过炎症反应促进急性冠状动脉综合征的发生,二者与冠状动脉狭窄程度有关,可作为评估患者病情的指标。

Objective To explore the change of hypersensitive C-reactive protein（hs-CRP） and uric acid in acute coronary syndrome and their relationship with coronary artery stenosis.Methods 80 cases with acute coronary syndrome proved by coronary angiography were selected as research subjects,including 45 patients with unstable angina pectoris and 35 patients with acute myocardial infarction,30 cases of health people were selected as control group.The difference of hs-CRP and uric acid among three groups and their relationship with coronary artery stenosis were studied.Results Serum hs-CRP and uric acid in the patients with unstable angina pectoris and acute myocardial infarction were much higher than those in the control group（P 0.05）,but there was no significant difference between unstable angina pectoris and acute myocardial infarction patients（P 0.05）;with the increasing of coronary lesion vessels in acute coronary syndrome,serum hs-CRP and uric acid greatly increased（P 0.05）;Pearson correlation analysis results showed that there were significant correlation between hs-CRP and uric acid（r = 0.387,P 0.05）.Conclusion hs-CRP and uric acid may participate in the pathogenesis of acute coronary syndrome by inflammatory response.They have relationship with coronary artery stenosis and could be indexes for evaluating the disease condition.