黄疸新生儿血清中TORCH特异性抗体的检测意义

Detection significance of TORCH specificity antibodies in neonatal jaundice

目的探讨黄疸新生儿血清TORCH特异性抗体检测的意义,对临床早期诊断及治疗提供依据。方法选择2011年1月～4月我院住院新生儿黄疸病例100例(新生儿黄疸组),另选择我院同期的非黄疸新生儿100例作为对照组,所有新生儿均采用酶联免疫吸附法(ELISA)检测TORCH-IgM抗体,观察两组TORCH感染情况。结果本研究中200例新生儿,IgM抗体阳性34例,阳性率17.0%。新生儿黄疸组100例中,TORCH-IgM阳性31例,IgM抗体检出率31.0%,对照组100例中TORCH-IgM阳性3例,IgM抗体检出率3.0%,两组TORCH-IgM抗体阳性率比较,差异有统计学意义(P<0.05),其中(CMV)感染占大多数。结论 TORCH抗体测定在新生儿黄疸诊治中的具有重要意义,也证实了TORCH病毒感染是新生儿黄疸病因之一。TORCH-IgM可作为TORCH及近期感染的依据,对辅助临床鉴别和治疗新生儿黄疸具有重要意义。

Objective To investigate the significance of TORCH specificity antibodies in neonatal jaundice,and to provide the evidence of early diagnosis and treatment.Methods 100 cases of neonatal jaundice in our hospital from January to April in 2011 were chosen as neonatal jaundice group,100 cases of newborn without jaundice in the same period were selected as control group.Enzyme-linked immune-sorbent assay（ELISA） was used to detect the TORCH-IgM antibody,TORCH infection was observed between the two groups.Results 34 cases of positive IgM antibody were found in all the 200 newborns,the positive rate was 17.0%.31 cases of positive TORCH-IgM antibody were found in neonatal jaundice group,detection rate of IgM antibody was 31.0%,3 cases of positive TORCH-IgM antibody were found in control group,detection rate of IgM antibody was 3.0%,the difference of rate of positive IgM antibody was statistically significant between the two groups（P 0.05）;the CMV infection was found to take the majority percentage.Conclusion TORCH antibody detection in neonatal jaundice diagnosis has the important meaning,the TORCH virus infection is one of the causes of neonatal jaundice.TORCH-IgM may be the basis for the TORCH and recent infection,and it has clinical significance to the identification and treatment of neonatal jaundice.