复方甘草酸苷联合阿维A治疗泛发性脓疱型银屑病临床分析

Clinical analysis of Compound Glycyrrhizin combined with Acitretin in the treatment of generalized pustular psoriasis

目的观察复方甘草酸苷联合阿维A治疗泛发性脓疱型银屑病的临床疗效。方法将64例泛发性脓疱型银屑病患者随机分成两组,各32例。治疗组静脉滴注复方甘草酸苷同时口服阿维A,对照组仅口服阿维A,疗程2个月。比较两组体温下降所需时间、无新发脓疱所需时间、皮损完全消退所需时间、平均住院时间、总有效率。结果治疗组体温下降所需时间为(4.26±1.32)d,无新发脓疱所需时间为(4.57±1.41)d,皮损完全消退所需时间为(18.74±3.43)d,平均住院时间为(21.76±3.78)d;对照组分别为(7.64±1.56)d、(7.66±1.62)d、(28.17±5.38)d、(32.42±5.61)d,两组比较差异均有统计学意义(均P<0.05)。治疗组总有效率为84.38%,对照组为59.38%,治疗组的总有效率明显高于对照组(χ2=4.95,P<0.05)。结论复方甘草酸苷联合阿维A治疗泛发性脓疱型银屑病疗效明显优于单用阿维A,并且起效快,不良反应少,值得临床推广。

Objective To observe effect of Compound Glycyrrhizin combined with Acitretin in the treatment of generalized pustular psoriasis.Methods 64 patients with generalized pustular psoriasis were randomly divided into two groups,each of 32 cases.The treatment group was given intravenous Compound Glycyrrhizin and oral Acitretin,the control group was only given oral Acitretin;the course was 2 months.The body temperature hypothermia time,no new pustules time,lesions completely subsided time,average hospitalization times,total efficiency of two groups were compared.Results In the treatment group,body temperature hypothermia time was（4.26±1.32） d,no new pustules time was（4.57±1.41） d,lesions completely subsided time was（18.74±3.43） d,average hospitalization times was（21.76±3.78） d;while they were（7.64±1.56） d,（7.66±1.62） d,（28.17±5.38） d,（32.42±5.61） d respectively in the control group;there were significant differences between two groups（all P 0.05）.The total effective rate of treatment group was 84.38%,which of control group was 59.38%,the total effective rate of treatment group was significantly higher than the control group（χ2=4.95,P 0.05）.Conclusion The effect of Compound Glycyrrhizin combined with Acitretin in the treatment of generalized pustular psoriasis is significantly better than Acitretin only,and it works faster,has less adverse reactions,which is worthy of clinical promotion.