摘要
目的综述药物诱发的急性肾功能损伤的发生机制。方法参考国内外文献,对免疫介导的损伤、细胞氧化损伤、细胞钙稳态紊乱等细胞毒性进行分类、归纳整理。结果大多数肾小球损伤由免疫介导的损伤引起,原发性肾小管-间质性损伤主要由药物、重金属等细胞毒性作用引起。结论药物源性肾损伤机制包括药物致肾小球滤过功能障碍和药物致肾小管功能障碍。
Objective To review the genesis mechanism of drug-induced renal injury.Methods By reviewing the literature,the cytotoxicity of immune mediated injury,oxidative cell injury and abnormal intracellular calcium homeostasis was categorized and analyzed.Results The glomerular damage is mainly caused by immune reaction,and primary renal tubular-interstitial damage is mainly caused by cytotoxicity of drug,heavy metals and so on.Conclusion The mechanism of drug-induced renal injury includes glomerular filtration dysfunction and renal tubular dysfunction.
出处
《中国药事》
CAS
2012年第12期1388-1392,共5页
Chinese Pharmaceutical Affairs
关键词
肾毒性
免疫损伤
自由基
细胞毒性
钙稳态
nephrotoxicity
immune injury
free radicals
cytotoxicity
calcium homeostasis
