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Polo样激酶抑制剂在肿瘤治疗中的应用 被引量：2

The Application of Polo-like Kinase Inhibitor for Cancer Therapy
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摘要 Polo样激酶(PLK)是一类高度保守的丝氨酸/苏氨酸蛋白激酶,在细胞有丝分裂调控点上发挥重要作用。大约80%的人类肿瘤都表达高水平的PLK,PLK在肿瘤中过度表达而在正常细胞中很少表达的特性使之成为一种很好的抗癌靶点。PLK抑制剂可以干扰癌细胞有丝分裂的不同阶段,如中心体成熟、纺锤体形成、染色体分离、胞质分裂等,导致有丝分裂停滞,严重干扰细胞周期进程,最终导致癌细胞死亡。当前,有一些PLK抑制剂处于临床前研发阶段,有些正处在临床试验阶段。全文着重论述近年来PLK抑制剂在肿瘤治疗中的应用。
作者 宋启斌 褚玉新 王桂华
机构地区 武汉大学人民医院肿瘤中心
出处 《中国肿瘤》 CAS 2013年第1期37-40,共4页 China Cancer
关键词 Polo样激酶 有丝分裂 肿瘤 抑制剂
分类号 R730.5 [医药卫生—肿瘤]
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参考文献21

  • 1卢帅,吴梦秋,颜婷婷,陈亚东,陆涛.Polo样激酶1及其小分子抑制剂的研究进展[J].药学进展,2010,34(3):97-104. 被引量：3
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二级参考文献31

  • 1熊福银,刘慧远,陈红星,邓继先.丝/苏氨酸蛋白激酶Plk1研究进展[J].中国生物工程杂志,2007,27(5):142-145. 被引量：3
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中国肿瘤
2013年 第1期

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