文拉法辛与舍曲林治疗重性抑郁症的对照研究

A Comparison Study of Venlafaxina and Sertraline of Depressive Patients

目的:比较文拉法辛与舍曲林治疗抑郁症的临床疗效和不良反应。方法:66例抑郁症患者进行文拉法辛和舍曲林的对照研究,其中文拉法辛组33例(75～250mg/d),舍曲林组33例(20～60mg/d),共8周。采用汉密尔顿抑郁量表(HAMD)评定疗效,副反应量表(TESS)评定不良反应。结果:经8周治疗后,文拉法辛与舍曲林疗效相当,没有严重副反应,但能较快控制症状。结论:文拉法辛是一种安全、有效的新一代抗抑郁药,适合临床使用。

Objective：The aim of this study was to determine the efficacy and side effects of venlafaxina and sertraline to the depressive patients.Method：A controlled study was carried out between 66 patients.The 33 of total patients were treated with venlafaxina（75-250 mg/d） and others were treated with sertraline（20-60 mg/d） for 8 weeks.The efficacy and safety were evacuated with HAMD and TESS respectively.Result：After eight weeks treatment,venlafaxina was as effective as sertraline without severe side effects.But it effected rapidly.Conclusion：Venlafaxina is an effective antidepressant,with less side effects,better safety and rapid response compared with sertraline,suiting for clinical use.