胎婴儿成红细胞增多症4例尸检分析

Erythroblastosis:an autopsy study of 4 cases

目的观察成红细胞增多症胎婴儿的临床病理特点,并对其发生机制进行分析。方法对4例成红细胞增多症胎婴儿的临床表现、外形、内脏结构以及胎盘形态进行观察分析。结果 4例成红细胞增多症均伴有胎儿水肿和腹腔积液,胎婴儿肝、脾、肺或肾中可见有核红细胞,胎盘绒毛肿大和水肿,胎盘血管中可见幼稚红细胞。结论胎婴儿成红细胞增多症的主要病理改变为全身脏器血管内可见大小不一、幼稚不成熟的有核红细胞,其发生与母婴血型不合有密切关系。

Abstract： Objective To observe the clinicopathologic features of erythroblastosis and to study the pathogenesis of erythroblastosis. Methods Four cases of erythroblastosis were observed with analyses of clinical features, their externalities and the structures of viscera and placenta. Results In the four cases of erythroblastosis associated with fetal hydrops, seroperitoneum and erythrocytoblast were noted in the liver, spleen, lung, kidney, placental villus intumesce; immature akaryocyte was seen in the placental vessel. Conclusions The main pathologic changes of fetus erythroblastosis are varying sized and immature erythrocytoblast in the blood vessels of all the organs. The pathogenesis of erythroblastosis may be related with blood type incompatibility between the mother and infant.