卵巢非特异性类固醇细胞瘤临床病理观察

Ovarian steroid cell tumor,not otherwise specified:a case report and review of literature

目的探讨卵巢非特异性类固醇细胞瘤的临床病理特点。方法对1例卵巢非特异性类固醇细胞瘤进行HE染色、光镜观察、免疫组化及特殊染色,并结合临床资料进行文献复习。结果肿瘤组织学形态显示,瘤细胞呈圆形或多边形,细胞胞质较宽,嗜酸性颗粒状或透明空泡状,肿瘤内薄壁窦状血管较为丰富。免疫组化:瘤细胞特征性α-inhibin、calretinin、CK-pan和CD99(+)。特殊染色显示苏丹Ⅲ(+),PAS(-)。结论卵巢非特异性类固醇细胞瘤是一种极少见的肿瘤,组织病理学特点结合免疫组化标记有助于该瘤的确诊。

Abstract： Objective To investigate the clinicopathological features of ovarian steroid cell tumor. Methods One case of ovarian steroid cell tumor specimen were investigated with HE staining, light microscopy, immunohistochemical （SP method） staining and special staining. The data of clinical diagnosis and treatment were reviewed. Results The characteristic histological patterns of the tumor was that polygonal to round cells with distinct cell borders and an abundant cytoplasm. Cytoplasm was usually granular and eosinophilic or valcuolated. Thin sinusoidal blood vessels in the tumor were more abundant. Immunohistochemistry showed that the tumor cells typically expressed ct-inhibin, calretinin, CK-Pan, CD99 and so on. Special staining was positive for Sudan m, and negative for PAS. Conclusion Ovarian steroid cell tumor, not otherwise specified, is a rare tumor. Pathological characteristics combined with immunohistochemistry is important in the final confirmation of the tumor.