胰腺印戒细胞癌四例临床分析

Signet ring cell carcinoma of pancreas： a report of 4 cases

目的 探讨胰腺印戎细胞癌的诊治.方法 回顾性分析天津肿瘤医院收治的、经手术病理证实的胰腺印戒细胞癌患者临床资料.结果 共4例胰腺印戒细胞癌病例,临床表现无特异性,主要症状有：上腹胀痛,可伴背痛和皮肤、巩膜黄染.1例患者癌抗原19-9和癌胚抗原增高.4例患者均行姑息性短路手术,术中行活检.平均生存期为2.8个月.结论 胰腺印戒细胞癌发病率低,预后差.手术是目前有效的治疗手段,但切除率低.化疗效果有待进一步证实.

Objective To analyze the investigation and treatment of signet ring cell carcinoma of pancreas.Method The clinical data of patients with histopathologically confirmed signet ring cell carcinoma of pancreas were analyzed retrospectively.Results There were 4 patients with signet ring cell carcinoma.There was no patient who presented with a typical carcinoid syndrome.Most patients presented with upper abdominal pain,backache or jaundice caused by bile duct obstruction.In one patient CA19-9 and CEA were raised.All patients received palliative biliary bypass and needle biopsy of the tumour.The median survival was 2.8 months.Conclusions Pancreatic signet ring cell carcinoma is a rare disease with poor prognosis.Surgery is the only effective treatment but the resectability rate is low.Whether this tumour responds to chemotherapy requires further studies.