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MicroRNA在胰腺癌中的研究进展 被引量：11

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摘要 微小RNA（miRNA）是一类长度为19～25个核苷酸的单链RNA，是由Dicer酶从折叠的70-100个核苷酸的发夹状转录前体RNAs（pre-microRNAs）上切割得到的小分子RNAs，主要通过与靶信使RNA（mRNA）的3’-非翻译区（3’-UTR）碱基配对的方式来执行对靶mRNA的切割或者翻译抑制功能，抑制靶基因表达而起调控作用[1]。
作者 胡伟 肖卫东
机构地区 南昌大学第一附属医院普通外科
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2013年第1期182-183,共2页 Chinese Journal of Experimental Surgery
基金 江西省自然科学基金资助项目（2010GZY0316）
关键词 MICRORNA 胰腺癌 非翻译区 靶基因表达 RNAS 抑制功能 mRNA 碱基配对
分类号 R735.9 [医药卫生—肿瘤]
  • 相关文献

参考文献24

  • 1Bartel DP. MicroRNAs:target recognition and regulatory functions[J].Cell,2009,(2):215-233.doi:10.1016/j.cell.2009.01.002.
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  • 4杨尹默,郝昆,田孝东.胰腺癌基础研究的几个热点问题[J].中华实验外科杂志,2012,29(1):13-15. 被引量：7
  • 5Roldo C,Missiaglia E,Hagan JP. MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior[J].Journal of Clinical Oncology,2006.4677-4684.
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二级参考文献28

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共引文献18

同被引文献72

  • 1程文,位志峰,高建平,张征宇,葛京平,景抗震,徐锋,解鹏.Effects of Combined siRNA-TR and-TERT on Telomerase Activity and Growth of Bladder Transitional Cell Cancer BIU-87 Cells[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2010,30(3):391-396. 被引量：3
  • 2Lujambio A,Portela A,Liz J,et al. CpG is-land hypermethylation-associated silencingof non-coding RNAs transcribed from ultra-conserved regions in human cancer [ J].Oncogene,2010,29(48) :6390-6401.
  • 3Schrammel A,Mussbacher M2,W(o)lkart G3,et al.Endothelial dysfunction in adipose triglyceride lipase deficiency[J].Biochim Biophys Acta,2014,1841 (6):906-917.
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  • 5Zheng L,Lv GC,Sheng J,et al.Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression,a novel mechanism for the pathogenesis of NAFLD[J].J Gastroenterol Hepatol,2010,25 (1):156-163.
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  • 8Ruimin Ma,Tao Jiang,Xixiong Kang. Circulating microRNAs in cancer:origin,function and application[J].Journal of Experimental &Clinical Cancer Research,2012,(38):2-9.
  • 9Yu J,Li A,Hong SM. MicroRNA alterations of pancreatic intraepithelial neoplasias[J].Clinical Cancer Research,2012,(04):981-992.
  • 10Sadakari Y,Ohtsuka T,Ohuchida K. MicroRNA expression analyses in preoperative pancreatic juice samples of pancreatic ductal adenocarcinoma[J].JOP,2010,(06):587-592.

引证文献11

二级引证文献28

中华实验外科杂志
2013年 第1期

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