托拉塞米注射液和呋塞米治疗脑卒中后脑水肿的疗效对比观察

Torasemide Injection and Furosemide of the Brain of the Stroke Edema Comparative Study

目的观察特苏尼(托拉塞米注射液)与呋塞米治疗脑卒中后脑水肿的疗效。方法将我科128例各种原因导致脑卒中后引起脑水肿患者随机分为两组。观察组给与20%甘露醇125ml+特苏尼20mg。对照组给与20%甘露醇125ml+呋塞米20mg。两组均1次/6h,然后逐渐减量。脑出血患者给予止血药物(氨甲环酸);脑梗死者给予扩血管、活血化瘀药物。两组常规给予抗生素预防继发颅内感染,西咪替丁预防和治疗消化道出血、溃疡,加强护理,维持水、电解质平衡及营养支持治疗,同时保持患肢功能体位,加强被动运动,重症者给予心电监护、吸氧、吸痰等,并记录每小时及24h尿量,两组疗程均为14d。结果治疗组疗效优于对照组,差异有统计学意义(P<0.05)。观察组不良反应少,相对比较安全。结论不论从疗效还是安全性来说,特苏尼较呋塞米有更为优越的治疗价值。

Objective Torasemide Injection and Furosemide in stroke compared the effect of the head edema.Methods Collect I branch 128 cases of all causes caused by cerebral edema after stroke patients were randomly divided into two groups：Observation group give 20% mannitol 125 ml＋ Torasemide Injection20 mg.Control group give 20% mannitol 125 ml＋ Furosemide 20 mg.Both groups q6h,Then gradually reducing.Cerebral hemorrhage patients to stop bleeding drugs,The cerebral infarction to enlarge the blood vessels,For activating blood circulation and eliminating stasis drugs,Two groups of conventional given antibiotics to prevent secondary intracranial infection,cimetidine The prevention and treatment of gastrointestinal bleeding,ulcer,Ulcer intensive care,keep the water,electrolyte balance and nutrition support therapy,and keep the limb function postures,strengthen the passive sport,The critical to remote ecg monitoring,oxygen,sucking phlegm,etc,The critical to remote ecg monitoring,oxygen,sucking phlegm,etc and record every hour and 24 hours of urine,two groups of course are 14 days.Results Effective treatment group was better than control,statistical significance（P〈0.05）,The observation group fewer side effects,the relative safety.Conclusion No matter from the curative effect or for safety Furosemide,Torasemide Injection the rice has more superior therapeutic value.