巨噬细胞刺激蛋白及其受体酪氨酸激酶RON在慢性阻塞性肺疾病炎性机制中的作用

Role of macrophage-stimulating protein and receptor tyrosine kinase RON in inflammation mechanism ofchronic obstructive pulmonary disease

慢性阻塞性肺疾病（chronicobstructivepulmonarydisease，COPD）是一种以气道炎症为特征的慢性炎症性疾病，肺泡巨噬细胞在其中的作用正逐渐被人们所重视。巨噬细胞刺激蛋白（MSP）及其受体酪氨酸激酶RON是近年来倍受关注的一类细胞因子，本文就MSP／RON对巨噬细胞的调节及其在COPD的炎性机制中的作用作一综述。

Chronic obstructive pulmonary disease （COPD） is a chronic inflammatory disease characterized by airway inflammation, for which the role of alveolar macrophages （AM） has been paid increasing attention to. Macrophage-stimulating protein （MSP） and receptor tyrosine kinase RON are one group of the cytokines that have received much attention in recent years. This review aimed to summarize the mechanism how MSP/RON regulated macrophages and their role in the inflammation process of COPD.