慢性阻塞性肺疾病骨骼肌功能障碍发病机制的研究进展

Research progress of pathogenesis of skeletal muscle dysfunction in chronic obstructive pulmonary disease

慢性阻塞性肺疾病（chronicobstructivepulmonarydisease，COPD）是一种具有气流受限为特征的肺部疾病，骨骼肌功能障碍（skeletalmuscledysfunction，SMD）是常见的并发症。目前研究多认为其主要发病机制为营养不良、慢性缺氧、炎症反应、氧化应激以及蛋白合成与分解失衡等。本文对近年来COPD合并SMD的相关机制研究进行综述，为进一步开展相关研究提供依据。

Chronic obstructive pulmonary disease （COPD） is a disease characterized by airflow limitation, and skeletal muscle dysfunction （SMD） as a common complications. Most researches considered that its main pathogenesis were malnutrition, chronic hypoxia, inflammation, oxidative stress and imbalance of protein synthesis and degradation. This review focuses on recent mechanism studies of COPD complicated with SMD, and provides basis for further research.