高泌乳素血症与男性精神分裂症患者疗效的相关性研究

Analysis of association between hyperprolactinemia and the effect of male patients with schizophrenia

目的:研究高泌乳素(PRL)血症与男性精神分裂症患者疗效的关系及其对病人生活质量的影响。方法:选择男性精神分裂症住院患者60例,观察治疗6个月。将其中治疗后出现高泌乳素血症的32例作为研究组,将治疗后未出现高泌乳素血症的28例作为对照组,采用阳性与阴性症状量表(PANSS)在治疗前后分别评定一次。以生活质量综合评定问卷(GQOLI)评定病人的生活质量。结果:研究组PANSS减分高于对照组(P<0.05),治疗后PRL水平较高、治疗前后差异较大或治疗前PRL水平较高者疗效较好,尤其是阳性症状改善明显。GQOLI总分、躯体健康纬度、心理健康纬度、社会功能纬度较入组时分值亦下降(P<0.01);与对照组比较分值显著下降(P<0.01)。结论:男性精神分裂症患者治疗前后血浆PRL水平与疗效有关。伴有高泌乳素血症的男性精神分裂症患者生活质量有所下降。

Objective：To investigate the influences of hyperprolactinemia on the efficacy and lite quality of male patients with schizophrenia. Methods：60 male schizophrenics were divided into research group including 32 patients with hyperprolactinemia alld controlled group including 28 patients without hyperprolactinemia. The patients assessed with the positive and negative syndrome scale （PANSS） before and after treatment. General quality of life inventory （GQOLI） assessed life quality. Results： At the end of 6th month ,the reduction rate of PANSS was significantly higher in research group than in controls （ P 〈 0.05 ）. Compared with the beginning, the total score of GQOLI and factor scores of physical function, mental health and social function decreased significantly（ P 〈0.01 ）. Con- clusions： The prolactinemia level is related to effects. Male schizophrenics with hyperprolactinemia have lower life quality than those without hyperprolactinemia.