布拉氏酵母菌联合三联疗法治疗儿童幽门螺杆菌感染疗效分析

Clinical effect about Boulardii powder combined triple therapy treating Helicobacter-pylori infection in children

目的:探讨布拉氏酵母菌联合三联疗法(奥美拉唑每天0.6 mg/kg,晨空腹顿服;克拉霉素每天15 mg/kg,分2次口服;阿莫西林每天50 mg/kg,分3次口服)治疗儿童幽门螺杆菌(Hp)感染临床疗效。方法:选择经胃镜检查、尿素酶试验和14C尿素呼气试验证实为幽门螺杆菌感染的胃炎患儿60例,随机分为治疗组和对照组,治疗组在三联疗法的基础上加用布拉氏酵母菌散口服(0.25,Bid),对照组只用三联疗法治疗,总疗程均为2周。比较两组Hp根除率、不良反应发生率。结果:治疗组Hp根除率、不良反应发生率与对照组相比差异均有统计学意义(P<0.05)。结论:在被Hp感染的胃炎患儿,布拉氏酵母菌能提高三联疗法治疗儿童Hp感染根除率,并减少胃肠道不良反应,值得临床推广。

Objective： To discus and evaluate the clinical effect of boulardii powder combine triple therapy （omeprazole and clarithromycin and amoxicillin） treating Helicobacter- pylori（Hp） infection in children with gastritis. Methods ：60 with gastritis chil- dren （by gastroscope, 14C urea breath test rapid urease test） were divided into two groups randomly. One is treating group （30cases, group A） , the other is control group（30cases,group B）. Group A was treated by boulardii powder and triple therapy, while group B only was treated by triple therapy. After 2 weeks, Compared the Hp eradicate rate and adverse reactions between the two groups. Re- suits ： The Hp eradicate rate, adverse reaction rate of group A compared with the group B differences were statistically significant （ P 〈 0, 05 ）. Conclusions： Bouiardii powder combine triple therapy can improve the Hp eradicate rate, and reduce gastrointestinal adverse reaction rate in children with gastritis. It is worthy of clinic application widely.