绍兴地区男女泌尿生殖道支原体感染特点及药敏差异分析

The characteristics and drug susceptibility differences of Mycoplasma and Ureaplasma infection in between male and female urogenital infections in Shaoxing

目的了解绍兴地区男女泌尿生殖道支原体属感染的特点,比较男女两性对几种抗菌药物的耐药情况的差异。方法应用法国生物梅里埃公司MycoplasmaISI试剂盒对2010年1月至2011年10月男女两性泌尿生殖道标本进行支原体培养及药敏试验,统计解脲脲支原体和人支原体的检出率及耐药情况。结果共1 722例泌尿生殖道感染病例中,支原体属阳性869例,总阳性率50.46%,其中单纯解脲脲原体(Uu)感染702例,单纯人型支原体(Mh)感染29例,Uu及Mh混合感染138例;714例男性中支原体阳性190例,阳性率26.61%,1008例女性中支原体阳性679例,阳性率67.36%;男性单纯Uu感染耐药率较高的主要是:环丙沙星(80.50%)、氧氟沙星(63.60%),女性单纯Uu感染耐药率较高的主要是:环丙沙星(91.97%)、氧氟沙星(73.72%)、红霉素(47.81%)。男女两性单纯Uu感染对红霉素、阿奇霉素、克拉霉素和交沙霉素的敏感性差异有统计学意义(P<0.05)。结论男女两性泌尿生殖道支原体感染以Uu为主,且两者对多种抗菌药物的敏感性具有显著性差异,临床应根据药敏结果合理选取使用抗菌药物。

Objective To explore the characteristics of urogenital infections by Mycoplasma and Ureaplasma in male and female patients in Shaoxing,and compare the antimicrobial drug resistance between male and female.Methods MycoplasmaISI kit of the French bioMerieux company was applied to the specimens from male and female urogenital tracts for Mycoplasma culture and drug sensitive test from January 2010 to October 2011;the detection rates and drug resistance of Ureaplasma urealyticum and Mycoplasma were analysed.Results In the total 1 722 patients with urogenital tract infection,869 cases were Mycoplasma positive and the total positive rate was 50.46%,including 702 cases infected by pure U.urealyticum（Uu）,29 cases by pure human M.Hominis（Mh）,and 138 cases by both Uu and Mh.In the 714 male patients,190 were Mycoplasma positive and the positive rate was 26.61%,while in the 1 008 female patients,679 were Mycoplasma positive（67.36%）.The pathogens in Male with pure Uu infection had high resistance rate to Ciprofloxacin（80.5%） and Ofloxacin（63.6%）,while in female with pure Uu infection,the pathogens had high resistance rate to Ciprofloxacin（91.97%）,Ofloxacin（73.72%） and erythromycin（47.81%）.The sensitivity differences between male and female with pure Uu infection to erythromycin,azithromycin,clarithromycin and josamycin had statistical significances（P0.05）.Conclusion Mycoplasma infection of Male and female urogenital tracts is mainly caused by Uu,which has high drug resistance to most antibiotics.Clinical rational medication should be based on antimicrobial susceptibility test results.