女性生殖道支原体感染现状及耐药性调查分析

Analysis on the status of mycoplasma infection in female genital tract and its resistance

目的了解女性生殖道支原体感染现状及耐药性,采取有效措施降低感染率,同时为临床合理用药提供依据。方法对415例疑似生殖道感染标本采用珠海迪尔生物有限公司生产的试剂盒进行支原体培养和药敏试验。结果 415例女性生殖道标本中,支原体感染209例,阳性率为50.4%(209/415),其中单纯解脲脲原体(Uu)感染141例,阳性率34.0%(141/415),单纯人型支原体(Mh)感染25例,阳性率6.0%(25/415),Uu和Mh混合感染43例,阳性率为10.4%(43/415);药敏试验结果表明:Uu、Uu+Mh、Mh对强力霉素、交沙霉素、美满霉素、四环素敏感性普遍较高,相反对红霉素、环丙沙星、罗红霉素、氧氟沙星等敏感性较差。结论女性生殖道支原体感染率较高,已婚育龄妇女应加强妇科检查,做到早检查、早诊断、早治疗。同时,临床医生应结合药敏试验结果合理用药,以降低女性生殖道支原体感染的发生率。

Objective To investigate the status of mycoplasma infection and its resistance,so that the doctors could take effective measures to reduce the infection rate and gain the evidence for clinical use of drugs.Methods Drug sensitivity test and culture of mycoplasma were performed on the specimens from 415 patients with genital tract infection by using the kits produced by Zhuhai Dier biotic Ltd.Results Among these 415 patients,209 were infected and the positive rate was 50.4%（209/415）,including Ureaplasma urealyticum（Uu） 34.0%（141/ 415）,Mycoplasma hominis（Mh） 6.0%（25/415）,and Uu＋Mh 10.4%（43/415）.The results of the drug sensitivity test showed that Uu,Uu＋Mh and Mh were sensitive to deoxycycline,josamycin,minocycline and tetracycline,and less sensitive to erythrocin,ciprofloxacin,roxithromycin,Ofloxacin and so on.Conclusion The rate of female genital mycoplasma infection is high and should be paid more attention.Gynecological exam of married women of childbearing age should be further promoted.Meanwhile,doctors should use drugs rationally to cut the rate of female genital mycoplasma infection.