酪酸梭菌的研究进展

Progress on Clostridium butyricum research

酪酸梭菌为革兰阳性厌氧芽孢杆,作为微生态制剂,在临床有着广泛的应用,可以调理人体胃肠功能;能大幅度降低伪膜性肠炎的发病率;对菌群失调引起的腹泻、抗生素相关性肠炎、便秘等有良好疗效。然而,关于酪酸梭菌引起肉毒中毒,使得酪酸梭菌再次成为研究热点。本研究就酪酸梭菌研究历史、临床应用、致病性等方面作一个简要综述。

Clostridium butyricum is a gram-positive anaerobic bacillus.As a kind of probiotics widely used in clinical,it can not only adjust gastrointestinal function of human,but also greatly reduce the incidence of pseudomembranous colitis.In addition,it has a good effect on the flora dysbacteriosis caused by diarrhea,antibiotic associated colitis,and constipation,etc..However,Clostridium butyricum becomes a hotspot of research again for Clostridium butyricum Botulism.This paper presents a brief review of Clostridium butyricum concerning its history of research,clinical application,pathogenicity and other advances.