江西省药品不良反应发生时间规律的探讨

Exploration on the Regularity of Occurrence Time of Adverse Drug Reactions in Jiangxi Province

目的:探讨药品不良反应(ADR)发生时间的分布规律,为ADR监测和防控工作提供参考。方法:采用圆形分布法,对江西省ADR监测中心2005-2011年收集的96895例次ADR发生的时间进行分析。结果:各年度上报的ADR数量基本呈逐年上升趋势;ADR发生的时间分布存在明显集中的趋势;各年度病例次数的月份分布趋势一致,且呈现位于8-10月的单峰,单峰的报告例次数占全年总报告例次数的38.3%;夏、秋季发病例次数明显高于冬、春季。ADR的高峰点为8月中旬。结论:应针对夏、秋季ADR高发的特点,提前采取应对措施,争取将ADR发生的风险降至最低。

OBJECTIVE： To investigate the regularity of occurrence time of adverse drug reactions（ADR）, and to provide ref- erence for ADR monitoring, prevention and control. METHODS： Circular distribution method was used to analyze the occurrence time of 96 895 ADR cases in Jiangxi province from 2005 to 2011. RESULTS： The number of ADRs showed an upward tendency; the occurrence time of ADRs showed an apparent central tendency, and single peak between Aug. to Oct., accounting for 38.3% of the total number： The number of ADRs in summer and autumn was significantly higher than in winter and spring. The peak point of ADRs occurred in mid-August. CONCLUSION： In order to provide effective information and reduce the risk of ADR, measures should be taken in advance before the peak seasons （summer and autumn） of ADR.