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脑钠肽及血管性血友病因子水平对老年急性冠脉综合征患者预后评估的价值 被引量：1

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摘要 目的通过观察老年急性冠脉综合征(ACS)患者血清脑钠肽(BNP)、血管性血友病因子(vWF)水平的变化,探讨BNP和vWF联合检测对老年ACS患者主要不良心脏事件(MACE)发生的预测价值。方法选择68例ACS患者,其中急性心肌梗死(AMI)36例,不稳定型心绞痛(UAP)32例,同时选择30例稳定性心绞痛(SAP)患者为对照组,检测各组患者入院当天血清BNP、vWF和心肌肌钙蛋白I(cTnI)水平,以及左室射血分数(LVEF),对各组患者进行Killip分级。所有患者平均随访180 d,观察随访期间主要不良心脏事件(MACE)的发生率。结果 ACS患者各组血清BNP、vWF水平均明显高于对照组,且对照组、UAP组、AMI组依次呈增高趋势,各组差异均有统计学意义。BNP与vWF、cTnI及Killip分级呈正相关,与LVEF呈负相关。BNP>532 pg/ml组随访期间出现MACE的例数明显高于BNP≤532 pg/ml组。BNP及vWF水平均升高的患者,MACE的发生率明显高于BNP或vWF升高者。结论 BNP和vWF水平与老年ACS患者危险分层相关,联合检测BNP及vWF水平对老年ACS患者MACE的发生有更好的预测价值。
作者 宗晓娜 李结华 唐海沁
机构地区 安徽医科大学第一附属医院老年心内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2013年第3期536-537,共2页 Chinese Journal of Gerontology
基金 安徽省教育厅自然科学研究重点项目(KJ2011A162)
关键词 脑钠肽 血管性血友病因子 急性冠脉综合征 预后
分类号 R541 [医药卫生—心血管疾病]
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参考文献9

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二级参考文献24

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中国老年学杂志
2013年 第3期

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