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高血压患者大脑认知功能与MoCA及P300的相关性研究 被引量:15

Relationship between MoCA,P300 and cognitive function in patients with hypertension
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摘要 目的:通过对高血压患者进行MoCA和P300的研究,了解其大脑认知功能状态。方法:以MoCA和P300为工具,检测50例高血压患者(高血压组)和50例正常者(对照组)的大脑认知功能状况。结果:与对照组比较,高血压组MoCA评分降低[(17.92±5.79)分∶(23.42±4.65)分],P300潜伏期延长[(377.56±35.72)ms∶(339.66±35.46)ms],均差异有统计学意义(均P<0.05)。P300潜伏期与白天平均舒张压呈负相关(r=-3.460,P=0.014),与白天脉压(r=0.353,P=0.012)、夜间平均收缩压(r=0.420,P=0.002)、夜间平均舒张压(r=0.309,P=0.029)及夜间脉压(r=0.305,P=0.003)均呈正相关。高血压组中,病程1~5年及≥5年者的P300潜伏期较对照组延长[(374.34±11.23)ms∶(390.45±12.11)ms∶(339.66±35.46)ms],MoCA评分较对照组降低[(19.78±2.05)分∶(16.42±3.45)分:(23.42±4.65)分]。结论:高血压患者存在潜在的认知功能障碍,且血压水平、昼夜节律变化及病程长短与认知功能障碍的发生有关。P300潜伏期对识别高血压患者潜在的认知功能障碍更为敏感。 Objective:To investigate the relationship between MoCA, P300 and cognitive function in patients with hypertension. Method:One hundred cases were divided into 2 groups: hypertension group (n= 50) and control group (n= 50). The MoCA and P300 were used to determine the cognitive changes. Result: P300 latency and MoCA scores in hypertension group were significantly different from control group (both P〈0.05). In hypertension group, P300 latency was negatively correlated with daily DBP (P= 0. 014), and positively correlated with daily PP (P=0. 012), and SBP (P = 0. 002), DBP (P= 0. 029), PP (P= 0. 003) at night. In hypertension group, P300 latency in the patients with duration of 1 to 5 years and over 5 years were significantly increased compared with control group [(374.34±11.23)ms vs (390.45±12.11)ms vs (339.66±35.46)ms], and the MoCA scores were decreased [(19. 78±2.05) vs (16.42±3.45) vs (23.42±4.65)]. Conclusion: Hypertensive patients have potential cognitive dysfunction which is related to blood pressure level, circadian rhythms and length of hypertension. P300 latency is more sensitive to identify cognitive dysfunction of hypertensive patients.
作者 刘忠玲 李华
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2013年第2期126-129,共4页 Journal of Clinical Cardiology
基金 新疆生产建设兵团科技攻关项目(No:2011BA041)
关键词 高血压 P300 MOCA 认知功能障碍 hypertension P300 MoCA cognitive dysfunction
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