动脉导管未闭封堵术后血小板减少原因分析及其防治

Analysis of the causes and prevention of thrombocytopenia after patent ductus arteriosus occlusion

目的:探讨动脉导管未闭(PDA)封堵术后血小板减少的原因及其防治。方法:对348例PDA行介入封堵术,分析术后并发血小板减少的可能原因。结果:348例中,并发血小板减少者8例,发生率为2.3%。8例PDA术后并发血小板减少者中,术后短暂残余分流5例;3例皮肤出现瘀斑瘀点并输注血小板;1例诊断考虑肝素相关性血小板减少症;1例因血小板减少明显,嗜酸粒细胞升高,转心外科取出封堵器+PDA结扎。除1例中转手术后血小板正常外,余7例于介入封堵术后1周～2个月血小板几乎恢复正常,均康复出院,无一例死亡。结论:PDA术后并发血小板减少症并不可怕,只要仔细分析其原因,是可以防治的。

Objective：To investigate the causes and prevention of thrombocytopenia after patent ductus arteriosus （PDA） occlusion. Method：In 348 patients underwent PDA occlusion, the causes and prevention of thrombocytopenia after operation were analyzed. Result： Eight （2.3%） cases complicated with thrombocytopenia. Postoperative transient residual shunt was in five cases. Ecchymosis and petechiae on the skin after operation was in three cases. One case was diagnosed heparin-related thrombocytopenia. One patient with significant thrombocytopenia and elevated eosinophils was removed the occluder and conducted the PDA ligation. All the patients were discharged without death..Conclusion：Thrombocytopenia after PDA is not terrible. As long as careful analysis of its causes, it can be prevented and cured.