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人体口腔微生物宏基因组的研究进展 被引量:13

Latest progress in unveiling the oral microbial metagenome
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摘要 人体生态环境中共生着数量庞大的微生物群落,被誉为人体第二基因组。口腔微生物与口腔及全身的健康和疾病有着密切的联系,新一代高通量基因芯片和第二代测序技术的涌现让人们对口腔微生物有了更全面的了解。本文就微生物宏基因组研究技术、口腔微生物宏基因组及其与口腔和全身疾病防治的最新进展进行综述。 The human resident microorganisms constitute the second genome of human body. Oral microbiome is closely related to the oral and systemic health and diseases. Implementation of high-throughput gene chip and second- generation sequencing has gained in-depth characterization of the oral microbiome, changing our view on host-microbe interactions. In this review, we summarized the latest progress in oral microbial metagenomics and addressed its poten- tial value in the prevention and treatment of oral diseases and other systemic disorders.
出处 《华西口腔医学杂志》 CAS CSCD 北大核心 2013年第1期107-111,共5页 West China Journal of Stomatology
基金 国家自然科学基金青年科学基金资助项目(81200782) 国家科技部“973计划”前期研究专项课题基金资助项目(2011CB-512108) 国家国际科技合作计划基金资助项目(2011DFA30940)
关键词 口腔微生物组 基因芯片 第二代测序 宏基因组 oral microbiome gene chip second-generation sequencing metagenomics
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