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组蛋白去乙酰化酶6与神经变性疾病 被引量：2

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摘要 神经变性疾病是一组由于中枢神经系统特定区域神经元发生变性而引起的慢性进行性疾病，主要包括帕金森病（Parkinson＇s disease，PD）、阿尔茨海默病（Alzheimer’s disease，AD）和亨廷顿舞蹈病（Huntington’s disease，HD）等，这些疾病均以异常蛋白质聚集和神经元选择性丢失为特征。虽然细胞自身具备清除这种蛋白质的途径，但是当其产生速度超过清除速度时，将会聚集并干扰细胞的正常功能。因此，寻找降解异常蛋白质的有效途径，对于治疗神经变性疾病具有重要意义。
作者 王飞 杜芸兰 李焰生
机构地区 上海交通大学医学院附属仁济医院神经内科
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2013年第1期10-10,22,33,43,47,共5页 Chinese Journal of Nervous and Mental Diseases
基金 国家自然科学基金资助项目(编号:81000538)
关键词 组蛋白去乙酰化酶6 神经变性疾病 聚集小体 自噬
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献25

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共引文献7

同被引文献18

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中国神经精神疾病杂志
2013年 第1期

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