Smac在干燥综合征患者唇腺组织中的表达

The expression of Smac in the labial gland of patients with Sjgren's syndrome

目的:检测干燥综合征患者唇腺组织中Smac的表达水平,探讨Smac在干燥综合征发病中的作用。方法:分别采用免疫组化和Western-blot方法对40例干燥综合征患者和22例非干燥综合征患者的唇腺组织中Smac蛋白进行检测,比较分析其在2组之间的差异。使用SPSS 12.0软件对数据进行t检验。结果:干燥综合征患者唇腺组织中Smac蛋白的表达明显高于非干燥综合征患者,2组之间差异具有显著性(P<0.05)。结论:Smac在干燥综合征患者唇腺组织中表达明显增高,提示其可能参与了发病过程。

Objective： To investigate the Smac level in the labial gland of patients with Sjogreng syndrome（SS） and preliminarily ex- plore the correlation between SS and Smac. Methods： Immunohistochemistry and Western-blot were used to examine Smac protein in labial glands in 40 patients with SS and 22 patients without SS. SPSS 12.0 software package was used for student t test. Results： The expression level of Smac protein in 40 patients with SS were higher than that in 22 controls（ P 〈 0.05 ）. Conclusion ： The expression of Smac is significantly increased in labial salivary glands in patients of SS, Smac may be associated with the pathogenesis of SS.