急性戊型肝炎血清甲胎蛋白浓度变化的观察

Change of serum alpha-fetoprotein concentration in acute hepatitis E

[目的]研究急性戊型病毒性肝炎(戊肝)患者甲胎蛋白(AFP)升高的特点与临床意义。[方法]检测、分析戊肝患者肝功能、AFP。[结果]20.3%的戊肝患者AFP升高;AFP升高的峰值可>3 000μg/L,AFP升高持续时间约4周。AFP升高及下降趋势与转氨酶有相似性,与总胆红素的消长不同步。戊肝AFP正常组与AFP升高组肝功能指标的峰值差异无统计学意义。[结论]急性戊肝患者可出现AFP重度升高;随病程逐渐减退,AFP升高与戊肝病情严重程度无明显关系,可能与急性肝炎后肝细胞再生活跃有关。

[Objective]To observe the change of serum alpha-fetoprotein（AFP） concentration in sporadic hepatitis E patients. [Methods]Sixty-four cases of serum AFP concentration and liver function were examined in sporadic hepatitis E patients. [Results]In all 64 sporadic hepatitis E cages, 13 cases（20.3%）were AFP positive. The maximum value of AFP concentration would be more than 3000 ng/ml. The increase of serum AFP concentration would last for about four weeks. The curve of AFP concentration was similar to amino transferases but different from bilirubin. There was no significant differences about maximum value of liver function between AFP positive cases and AFP negative cases. [Conclusion]AFP concentration may increase in sporadic hepatitis E patients, even severely. AFP level would decline during the course of disease. There was no correlation between AFP level and severity of hepatitis E. The regeneration of liver cells afer acute hepatit;s may cause the increase of AFP concentration in hepatitis E patients.