江西产银环蛇毒中K-神经毒素的分离纯化

Isolation and purification of Kappa-neurotoxins from Bungarus multicinctus venom collected in Jiangxi Province

利用 3次阳离子层析法从江西产银环蛇毒中分离得到 2个相对分子质量均为 6 50 0的K -神经毒素 进一步证实了K -神经毒素是银环蛇毒的基本成分 K -神经毒素是目前唯一的可用于烟碱受体分型的工具 它可高效地识别α3β2

Two Kappa-neurotoxins with a molecular weight of 6 500 dalton were isolated by three ion-exchange chromatographies from Bungarus multicinctus venom collected in Jiangxi Province, demonstrating further that Kappa-neurotoxins are the basic component of Bungarus multicinctus venom. Kappa-neurotoxins are now the only known toxin probes used to distinguish different subtypes of neuronal nicotinic acetylcholine receptors.