尿囊素化学合成的改进

Improvement of synthesizing allantoin

为使乙二醛的氧化反应平稳地启动 ,可在浓硝酸中加入少量乙醇。在氧化反应的过程中逐步地提高反应温度 ,反应后期进行减压浓缩 ,提高了乙醛酸的浓度 ,缩短了氧化时间 ,并使尿囊素产率达到 40 %。

To start the oxidation reaction of glaoxal smoothly,it is useful to add some alcohol (CH 3CH 2OH) to nitric acid.In the course of oxidation,reaction temperature should rise step by step,and in the late stage,reduced pressure distillation should follow so that the concertration of glyoxalic acid can rise and production rate of allantoin can rise up to 40%.